Cheesy Mississippi Sin Ham and Cheese Biscuit Breakfast Casserole

There’s something magical about a breakfast casserole that brings together all the flavors you love in one dish. As someone who adores both cooking and sharing meals with loved ones, I can confidently say that this Cheesy Mississippi Sin Ham and Cheese Biscuit Breakfast Casserole is a game-changer. It’s rich, indulgent, and packed with savory ham, gooey cheese, and fluffy biscuits—perfect for lazy weekend mornings, holiday brunches, or even a hearty dinner.

The inspiration for this recipe comes from the classic Mississippi Sin Dip, a crowd-pleaser known for its creamy, cheesy, and slightly spicy flavor profile. I decided to take those beloved elements and transform them into a breakfast casserole that’s equally irresistible. Whether you’re feeding a hungry family or hosting a brunch party, this dish is guaranteed to impress. Let’s dive into what makes this recipe so special and how you can recreate it at home.

What You Need To Make This Recipe

Biscuits: The base of this casserole is made with flaky, buttery biscuits. They soak up all the delicious flavors while maintaining a soft, tender texture. I recommend using refrigerated biscuit dough for convenience, but homemade biscuits work just as well if you’re feeling ambitious.

Ham: Diced ham adds a savory, smoky flavor to the casserole. It’s the perfect protein to balance out the richness of the cheese and cream. Use leftover holiday ham or grab a pre-diced package from the store to save time.

Cream Cheese: This is the secret ingredient that gives the casserole its creamy, luxurious texture. Softened cream cheese blends seamlessly with the other ingredients, creating a melt-in-your-mouth experience.

Sour Cream: Sour cream adds a tangy note and helps keep the casserole moist. It also complements the richness of the cream cheese and cheese blend.

Cheddar Cheese: Sharp cheddar cheese brings a bold, cheesy flavor that pairs perfectly with the ham. I recommend shredding your own cheese for the best meltability and flavor.

Green Onions: Finely chopped green onions add a fresh, slightly sharp flavor that cuts through the richness of the dish. They also add a pop of color for visual appeal.

Jalapeños: For a touch of heat, diced jalapeños are a must. They add a subtle kick that elevates the overall flavor profile. If you’re sensitive to spice, you can reduce the amount or omit them altogether.

Eggs: Eggs act as a binder, holding the casserole together and giving it a fluffy, custard-like texture.

Milk: A splash of milk helps create a smooth, pourable mixture that ensures even cooking.

Seasonings: A blend of garlic powder, onion powder, and a pinch of salt and pepper enhances the flavors of the other ingredients.

Ingredients List

1 can (16.3 oz) refrigerated biscuit dough
2 cups diced ham
8 oz cream cheese, softened
1 cup sour cream
2 cups shredded sharp cheddar cheese
1/2 cup finely chopped green onions
1/4 cup diced jalapeños (optional)
6 large eggs
1/2 cup milk
1/2 tsp garlic powder
1/2 tsp onion powder
Salt and pepper to taste

How to Make Cheesy Mississippi Sin Ham and Cheese Biscuit Breakfast Casserole

Step 1: Preheat and Prepare

Preheat your oven to 350°F (175°C) and lightly grease a 9×13-inch baking dish. This ensures the casserole doesn’t stick and makes cleanup a breeze.

Step 2: Prepare the Biscuits

Cut each biscuit into quarters and arrange them evenly in the bottom of the prepared baking dish. The biscuits will rise and create a fluffy base for the casserole.

Step 3: Mix the Filling

In a large bowl, combine the softened cream cheese, sour cream, shredded cheddar cheese, diced ham, green onions, and jalapeños (if using). Mix until everything is well incorporated.

Step 4: Prepare the Egg Mixture

In a separate bowl, whisk together the eggs, milk, garlic powder, onion powder, salt, and pepper until smooth. This mixture will bind everything together and give the casserole its custard-like texture.

Step 5: Assemble the Casserole

Pour the cream cheese and ham mixture over the biscuits, spreading it evenly. Then, slowly pour the egg mixture over the top, making sure it seeps into all the nooks and crannies.

Step 6: Bake to Perfection

Bake the casserole in the preheated oven for 40-45 minutes, or until the top is golden brown and the center is set. Let it cool for 5-10 minutes before serving.

Tips for Making this Recipe

Use Room Temperature Ingredients: Make sure your cream cheese, sour cream, and eggs are at room temperature before mixing. This ensures a smooth, even texture.
Customize the Heat: Adjust the amount of jalapeños to suit your spice preference, or leave them out entirely for a milder flavor.
Add Extra Veggies: Feel free to toss in diced bell peppers, spinach, or mushrooms for added nutrition and flavor.
Make Ahead: Assemble the casserole the night before, cover it, and refrigerate. Bake it in the morning for a stress-free breakfast.
Serve with Toppings: Garnish with extra green onions, a dollop of sour cream, or a drizzle of hot sauce for an extra flavor boost.

FAQs

Can I use a different type of meat?
Absolutely! Cooked bacon, sausage, or even turkey would work well in place of ham.

Can I make this recipe gluten-free?
Yes, simply use gluten-free biscuit dough and ensure all other ingredients are gluten-free.

How do I store leftovers?
Store any leftovers in an airtight container in the refrigerator for up to 3 days. Reheat in the microwave or oven before serving.

Can I freeze this casserole?
Yes, you can freeze the baked casserole for up to 2 months. Thaw it in the refrigerator overnight and reheat in the oven until warmed through.

What can I serve with this casserole?
This dish pairs well with fresh fruit, a simple green salad, or a side of hash browns for a complete meal.

This Cheesy Mississippi Sin Ham and Cheese Biscuit Breakfast Casserole is a true crowd-pleaser that’s as easy to make as it is delicious. Give it a try, and I promise it’ll become a staple in your recipe collection!